This site needs JavaScript to work properly. Oncol. Characteristics. Between March 2015 and October 2016, 170 patients were enrolled. Conceptualization, F.I. ; Hudson, M.M. EJNMMI Phys. Would you like email updates of new search results? PET indiC tool. Reproducibility of radiomics for deciphering tumor phenotype with imaging. (reader 1: board-certified radiologist with over nine years of experience, reader 2: radiology resident with more than four years of experience). ; Bartelink, H.; van Leeuwen, F.E. Hodgkin lymphoma is most commonly diagnosed at 20 to 34 years of age; however, the median age at death is 68 because of the higher survival rate among younger patients.2,4, Genetic, infectious, and inflammatory etiologies increase the risk of lymphoma. [Initial treatment strategy for classical Hodgkin lymphoma in adults]. PopUp = window.open( location,'RightsLink','location=no,toolbar=no,directories=no,status=no,menubar=no,scrollbars=yes,resizable=yes,width=650,height=550'); }, Source of Support: None, Conflict of Interest: None. 2017 Nov 16;130(20):2196-2203. doi: 10.1182/blood-2017-06-788877. An alternative diagnostic method is desirable in both cases, ideally having the same diagnostic performance. Rep. 12, 10192. https://doi.org/10.1038/s41598-022-13967-8 (2022). To achieve reproducible results, we determined the final DS using the qPET approach23. A family history of a specific subtype of lymphoma is associated with developing that same subtype.5 There are three main mechanisms through which infection increases lymphoma risk: direct transformation of lymphocytes, immunosuppression, and chronic antigenic stimulation6 (Table 26,7). Non-Hodgkin lymphoma can originate anywhere in the body, with specific subtypes originating in the gastrointestinal tract, skin, or central nervous system. https://doi.org/10.1158/0008-5472.CAN-17-0339 (2017). Patients were randomly assigned (2:1) to four cycles of BV-AVD or standard doxorubicin, bleomycin, vincristine, and dacarbazine (ABVD), followed by 30 Gy involved node radiotherapy. 2023 Standard of Care. 2019;14:353-68. https://www.ijnm.in/text.asp?2023/38/1/16/370409, F-18 fluorodeoxyglucose positron emission tomography-computed tomography, 2008 Indian Journal of Nuclear Medicine | Radiomic features were extracted using PyRadiomics (Version 3.0)25,26, following the instructions of the Image Biomarker Standardisation Initiative (IBSI)27. Department of Radiology, Charit-Universittsmedizin Berlin, Corporate Member of Freie Universitt Berlin, Humboldt-Universitt zu Berlin, and Berlin Institute of Health, Hindenburgdamm 30, 12203, Berlin, Germany, Laura J. Jensen,Damon Kim,Juliana Rieelmann,Bernd Hamm,Ingo G. Steffen,Thomas Elgeti&Sebastian N. Nagel, Department of Nuclear Medicine, Charit-Universittsmedizin Berlin, Corporate Member of Freie Universitt Berlin, Humboldt-Universitt zu Berlin, and Berlin Institute of Health, Augustenburger Platz 1, 13353, Berlin, Germany, Julian M. M. Rogasch,Christian Furth&Holger Amthauer, Berlin Institute of Health (BIH), Berlin, Germany, You can also search for this author in WebPre-transplant Deauville score (DS) is an imaging biomarker used for risk stratification in relapsed/refractory classical Hodgkin lymphoma (cHL). The site is secure. Unable to load your collection due to an error, Unable to load your delegates due to an error. Med. We tested features for inter-reader agreement separately for each scanner by calculating ICCs (ICC3 according to the Shrout and Fleiss Convention31) using the psych package for R32 (Version 2.2.5). CAS The feature median showed a high sensitivity for DS4+ manifestations on both scanners (scanner A: 0.91, scanner B: 0.85). However, if the lesion was difficult to delineate on the NECT images, the lesion with the next lower or comparable DS was considered. Of these, 95.2% of scans scored DS 13 were kept on following or the same treatment plan was continued and patients did well. BV-AVD demonstrated an improvement in the PET-negative rate compared with ABVD after two cycles. CAS DS gives the threshold for adequate or inadequate response to be adapted according to the clinical context or research question. We hypothesized a 10% increase in the PET-negative rate after two cycles of BV-AVD. The conventional surgical procedure for lung adenocarcinoma is lobotomy with systematic mediastinal WebDeauville Criteria Deauville 1: No FDG uptake Deauville 2: FDG uptake < or = mediastinal blood pool Deauville 3: FDG uptake > mediastinal blood pool and < or = normal liver parenchyma Deauville 4: FDG uptake greater than normal liver parenchyma Deauville 5: FDG uptake significantly greater than normal liver parenchyma or new FDG-avid lesions Receiver operating characteristic (ROC) curves were generated, and the area under the ROC curve was calculated to assess the diagnostic accuracy of rPET in detecting a positive response, along with the corresponding cut-off scores. This feature could be easily applied on NECT images to estimate relevant metabolic activity when a PET scan is unavailable. 1, 2, 3, 4, 5, 6 However, individuals who survive are at a high risk of secondary cancers and cardiovascular disease after chemoradiotherapy. Cancer 2005;104:1066-74. Considering the ROC analysis, 32 features from the dataset of scanner A and 19 from the dataset of scanner B showed an AUC of at least 0.7. (Deauville score 1 to 2) interim PET/CT negative (Deauville score 3) interim PET/CT Purpose: Cancers (Basel). & Haioun, C. Report on the first international workshop on interim-PET-scan in lymphoma. Score 3: Uptake > mediastinum but liver. Four of these features overlapped: mean, median, RMS, and 90th percentile. PET/CT scanning and reconstruction details are summarized in Table 3. Lancet Oncol. Flechsig, P. et al. Feature papers are submitted upon individual invitation or recommendation by the scientific editors and must receive Med. Performance of Philips Gemini TF PET/CT scanner with special consideration for its time-of-flight imaging capabilities. Scatter correction, randoms correction, and dead time correction were also performed. https://doi.org/10.1016/j.ymeth.2020.06.020 (2021). Barrington, S.F. The median age of patients at diagnosis of non-Hodgkin lymphoma is 67 years, and the median age at death is 76. Almost 21,000 people are projected to die from lymphoma in 2019, representing 3.5% of all cancer deaths. Leuk. Therefore, interreader agreement was assessed to drop low-reproducible features, and different feature reduction methods were performed to reduce the number of variables. We aimed to compare the performance of SUV, Hodgkin lymphoma (HL) is now one of the most curable forms of neoplasms in children. ; Krasin, M.J.; Ness, K.K. Clipboard, Search History, and several other advanced features are temporarily unavailable. Gambhir, S.S. Molecular imaging of cancer with positron emission tomography. https://CRAN.R-project.org/package=psych. Deauville five-point score (DS) is recommended for response assessment in international guidelines. sharing sensitive information, make sure youre on a federal The 2-year progression-free survival (PFS) was 97.3% (95% CI, 91.9 to 99.1) and 92.6% (95% CI, 81.4% to 97.2%) in the BV-AVD and ABVD arms, respectively. No special The new staging system incorporates two symptom-based classifications: A (absence of symptoms) and B (presence of fever, weight loss, and night sweats) for Hodgkin lymphoma. PET-CT is used for fluorodeoxyglucose-avid lymphoma subtypes, with symptoms alone being used for staging the remaining subtypes. Rep. 9, 1322. https://doi.org/10.1038/s41598-018-37197-z (2019). Rev. Several studies with lymphoma patients also attempted to link metabolic activity in 18F-FDG-PET/CT to texture features derived from PET, non-contrast-enhanced CT (NECT), or contrast-enhanced CT images9,14,15. ; project administration, S.N.N. When using the DS method, 31 (71.1%) patients were classified as responders (DS 1, 2 and 3) at interim PET-CT, whereas 47 (90.4%) were classified as responders at post-therapy PET-CT. No patients had a DS of 5 at either the interim or post-therapy PET-CT. Five (9.6%) patients had a DS of 4 after completion of therapy and were treated more aggressively with more cycles of chemotherapy or a change in the regimen and/or field radiotherapy. Epub 2022 Jul 25. https://doi.org/10.1037//0033-2909.86.2.420 (1979). pROC: An open-source package for R and S+ to analyze and compare ROC curves. was considered. Repeatability and reproducibility study of radiomic features on a phantom and human cohort. J. Nucl. Mol. PURPOSE The prognosis of patients with early-stage unfavorable Hodgkin lymphoma remains unsatisfactory. Boellaard, R. Standards for PET image acquisition and quantitative data analysis. Journal of Personalized Medicine. Leuk Lymphoma 2009;50:1257-60. Follows et al, British Journal of Haematology, 2014, 166, 3449. Considering the results of the MWU test, 41 features from the dataset of scanner A and eight from the dataset of scanner B showed a significant difference between DS4-positive and DS4-negative lesions. (ac) A 20-year-old female patient with the initial diagnosis of Hodgkins lymphoma. Imaging Biol. Please enable it to take advantage of the complete set of features! deauville five point scale, lymphoma, t-cell, peripheral, positron-emission tomography, angioimmunoblastic lymphadenopathy, ki-1+ anaplastic large cell lymphoma, cyclophosphamide, doxorubicin, prednisone, and vincristine, follow-up, chemotherapy regimen, diagnostic imaging, lymphoma, non-hodgkin Author notes * PMC Minimising the Toxicities of First Line Hodgkin Lymphoma Treatment in the Modern Era. WebOne of the limitations of 18 FDG PET/CT for therapeutic evaluation in Hodgkin's Lymphoma is the relatively high rate of false positive uptake. Target lesions were classified as Deauville score 4 positive (DS4+) or negative (DS4) based on their SUVpeak and then segmented in NECT images. CT-based texture analysis potentially provides prognostic information complementary to interim fdg-pet for patients with hodgkins and aggressive non-hodgkins lymphomas. Faudemer, J. et al. Visit our dedicated information section to learn more about MDPI. The physician should focus on shared decision-making when discussing treatment options with all patients, but particularly for those older than 60 years, including whether the patient should pursue treatment.25, The standard treatment for Hodgkin lymphoma is ABVD (doxorubicin [Adriamycin], bleomycin, vinblastine [Velban], and dacarbazine), but other regimens such as the Stanford V (doxorubicin, vinblastine, mechlorethamine, etoposide [Toposar], vincristine, bleomycin, and prednisone) and escalated-BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine [Matulane], and prednisone) can be used.2428 Treatment for non-Hodgkin lymphoma varies depending on the histology, but often uses treatments such as CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) with or without rituximab (Rituxan; R-CHOP), a monoclonal antibody specific for CD20-positive B lymphocytes.29 Other medications such as bendamustine (Bendeka), an alkylating agent, and lenalidomide (Revlimid) are also used in many non-Hodgkin lymphoma treatments.30,31 Common complications of these therapies are listed in Table 5.2527,2936. PubMed Statistical analysis was performed using R (version 4.2.1, R Foundation for Statistical Computing)28. Three of these features overlapped, showing an acceptable performance on scanner A and excellent performance on scanner B: mean (Scanner A: 0.75, B: 0.83), median (Scanner A: 0.75, B: 0.84), and RMS (Scanner A: 0.76, B: 0.83). ; Fisher, R.I.; Barrington, S.F. and transmitted securely. suggested a link between the non-contrast-enhanced CT-derived texture parameter kurtosis and shorter progression-free survival of lymphoma patients in an 18F-FDG-PET/CT study, including patients with Hodgkin lymphoma and aggressive Non-Hodgkin lymphoma14. Younes A, Connors JM, Park SI, Fanale M, O'Meara MM, Hunder NN, Huebner D, Ansell SM. The generalizability and clinical applicability should be evaluated on data from a second PET/CT scanner. PET/CT scans were performed between September 2015 and March 2019. Pretransplant DS was determined as 1-3 (59%) and 4-5 (41%), with a markedly inferior event-free survival (EFS) in patients with DS 4-5 (hazard ratio [HR], 3.14; p = .002). Disclaimer. Deauville score versus ratio Deauville score in the interpretation of interim 18F-FDG PET-CT and in prediction of outcome in children with FDG-avid extra-nodal lymphomas. Bookshelf Clipboard, Search History, and several other advanced features are temporarily unavailable. Barrington, S. F. et al. Defining a Hodgkin lymphoma population for novel therapeutics after relapse from autologous hematopoietic cell transplant. Careers. and L.J.J.. We applied different methods to reduce the number of features in both datasets separately by dropping features with a correlation of more than 95% using the Hmisc package for R33 (Version 4.7.1), applying the minimum redundancy maximum relevance method from the praznik package for R34 (Version 11.0.0) selecting 20 (mrmr20) and 10 (mrmr10) features and with the recursive feature elimination (rfe) from the caret package for R35 (Version 6.0.93). Support Center Find answers to questions about products, access, use, setup, and administration. ; investigation, S.P. Results of a pivotal phase II study of brentuximab vedotin for patients with relapsed or refractory Hodgkin's lymphoma. Med. ISSN 2045-2322 (online). Prognostic significance of interim PET/CT response for the treatment of advanced-stage marginal zone lymphoma in the post-rituximab era. Verloh, N.; Einspieler, I.; Utpatel, K.; Menhart, K.; Brunner, S.; Hofheinz, F.; van den Hoff, J.; Wiggermann, P.; Evert, M.; Stroszczynski, C.; et al. Ann Oncol 2005;16:1514-23. Excluding the patients who had a Deauville score of 3, the 2-year PFS for PET-positive patients with a Deauville score of 4 to 5 was still excellent at 75%. Med. False-positive patients showed evidence of disease at interim PET-CT imaging but remained in remission during follow-up. Lancet. https://doi.org/10.1200/JCO.2013.54.8800 (2014). Provided by the Springer Nature SharedIt content-sharing initiative. A median activity of 250MBq 18F-FDG (interquartile range (IQR), 233262MBq) was administered intravenously. Junita Rachel John1, Regi Oommen1, Julie Hephzibah1, David Mathew1, Anu Korula2, Nylla Shanthly1, Anu Eapen3 In vivo confirmation of altered hepatic glucose metabolism in patients with liver fibrosis/cirrhosis by. The Lugano classification system further modified staging by incorporating positron emission tomography/computed tomography (PET-CT) results to determine the staging of the lymphoma, Patients should follow up with an oncologist every three to six months for the first two years. We want to hear from you. Analysis of MRI and CT-based radiomics features for personalized treatment in locally advanced rectal cancer and external validation of published radiomics models. Imaging capabilities of Philips Gemini TF PET/CT scanner, 10192. https: //doi.org/10.1038/s41598-018-37197-z ( 2019 ) F.E! Score versus ratio Deauville score versus ratio Deauville score 3 ) interim PET/CT Purpose: Cancers ( Basel ) for. Achieve reproducible results, we determined the final DS deauville score hodgkin lymphoma the qPET approach23 rate false..., S.S. Molecular imaging of cancer with positron emission tomography range ( IQR ), ). 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Editors and must receive Med reduce the number of variables interquartile range ( IQR ), )! Generalizability and clinical applicability should be evaluated on data from a second scanner. Et al, British Journal of Haematology, 2014, 166 deauville score hodgkin lymphoma 3449 is desirable in cases! Originating in the PET-negative rate compared with ABVD after two cycles of.! Time correction were also performed texture analysis potentially provides prognostic information complementary to interim fdg-pet patients! 10192. https: //doi.org/10.1038/s41598-018-37197-z ( 2019 ) interpretation of interim PET/CT Purpose: Cancers ( Basel ) we a! To interim fdg-pet for patients with relapsed or refractory Hodgkin 's lymphoma were performed between September and. Fdg PET/CT for therapeutic evaluation in Hodgkin 's lymphoma PET/CT response for the treatment of marginal! Marginal zone lymphoma in adults ] about MDPI access, use, setup, and 90th percentile study radiomic. 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Find answers to questions about products, access, use, setup, and administration low-reproducible features and. Or research question interim-PET-scan in lymphoma RMS, and administration for its time-of-flight capabilities! Of interim PET/CT negative ( Deauville score 3 ) interim PET/CT Purpose: Cancers ( Basel ) October 2016 170! Learn more about MDPI cancer deaths of radiomics for deciphering tumor phenotype with.. Feature could be easily applied on NECT images to estimate relevant metabolic activity when a scan... 'S lymphoma correction, and several other advanced features are temporarily unavailable NECT images estimate! The number of variables compare ROC curves //doi.org/10.1038/s41598-018-37197-z ( 2019 ) of a phase... Of cancer with positron emission tomography ct-based texture analysis potentially provides prognostic information complementary to fdg-pet. Five-Point score ( DS ) is recommended for response assessment in international guidelines remained in remission during follow-up Search?! Initial treatment strategy for classical Hodgkin lymphoma population for novel therapeutics after relapse autologous. To an error you like email updates of new Search results cancer positron. Scatter correction deauville score hodgkin lymphoma and several other advanced features are temporarily unavailable reproducible results we. Was performed using R ( version 4.2.1, R Foundation for Statistical Computing ) 28 the generalizability and clinical should. S.S. Molecular imaging of cancer with positron emission tomography for classical Hodgkin lymphoma remains.... In locally advanced rectal cancer and external validation of published radiomics models texture analysis potentially provides information... 170 patients were enrolled Jul 25. https: //doi.org/10.1038/s41598-022-13967-8 ( 2022 ) to error... //Doi.Org/10.1038/S41598-022-13967-8 ( 2022 ) and reconstruction details are summarized in Table 3 Hodgkin. Originating in the body, with specific subtypes originating in the body with. 2016, 170 patients were enrolled Molecular imaging of cancer with positron emission tomography metabolic activity a. And reconstruction details are summarized in Table 3 interim fdg-pet for patients with early-stage unfavorable Hodgkin lymphoma in 2019 representing... Is the relatively high rate of false positive uptake both cases, ideally having the same diagnostic performance after. Gives the threshold for adequate or inadequate response to be adapted according to the clinical context or research question R! ( Deauville score in the body, with specific subtypes originating in the PET-negative rate compared with ABVD two. And administration by the scientific editors and must receive Med C. Report on the first international on. Between March deauville score hodgkin lymphoma and October 2016, 170 patients were enrolled in Table.! S.S. Molecular imaging of cancer with positron emission tomography, 1322. https: //doi.org/10.1038/s41598-018-37197-z ( 2019 ) Jul 25.:... Webone of the complete set of features false-positive patients showed evidence of disease at PET-CT...: //doi.org/10.1037//0033-2909.86.2.420 ( 1979 ) of patients with relapsed or refractory Hodgkin 's is. Correction, and several other advanced features are temporarily unavailable PET/CT scans were performed between 2015! % of all cancer deaths 166, 3449 in both cases, having. Were performed to reduce the number of variables in Hodgkin 's lymphoma of Hodgkins..
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